THERAPEUTIC TARGETING OF AUTOREACTIVE B CELLS: WHY, HOW, AND WHEN?

Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?

B lymphocytes play critical roles in the development of autoimmunity, acting as autoantibody manufacturers, antigen-presenting cells, and producers of cytokines.Pan-B cell depletion has demonstrated efficacy in treatment of many 1073spx autoimmune disorders, but carries with it an unfavorable safety profile due to global immune suppression.Hence, a

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